health π§ Tau buildup messes with brain signals in Alzheimer's
Tau accumulation is reshaping neurotransmitter signaling in Alzheimer's disease, a condition affecting 11% of those aged 65+ in the U.S. Researchers at the Korea Brain Research Institute studied AD mice, confirming hyperphosphorylated tau aggregation over time. Proteomic analysis of seven brain regions showed dysregulation in metabolic and cell cycle pathways. They found alterations in six neurotransmitters, specifically dopamine- and serotonin-signaling molecules. The findings suggest tau accumulation might cause neurotransmitter remodeling, pointing to new therapeutic targets.