π§ Supportive brain cells might cause cognitive decline
New research suggests that brain cells producing myelin, which is a protective coating on nerve fibers, can become dysfunctional with age. This study focused on participants from the Lothian Birth Cohort 1936, who had cognitive assessments between age 70 and 82. Researchers found that more severe decline was linked to unhealthy myelin and fewer large nerve fibers in post mortem tissue. They discovered reduced NRF2 protein in these cells drives this dysfunction, contributing to cognitive issues during aging. This opens possibilities for repurposing existing drugs to protect cognition later in life. π§