health Six SGLT2 inhibitor drugs share a mechanism but have different approved uses. Dapagliflozin and empagliflozin have indications for heart failure and CKD even without diabetes. Ertugliflozin and bexagliflozin are only approved for glycemic control in T2DM. Sotagliflozin targets heart failure and CKD but lacks a glycemic indication. Clinicians must match the specific labeled indication to the patient, as the amputation warning status also changed.
business Sunny Deol's last five films saw producers invest over 500 crore across the projects. Out of these five, only two achieved a clean hit, leading to a 40% success ratio for the actor. Gadar 2 stood out as the top earner, netting 525.50 crore against a 75 crore budget. Despite the low success rate, total net profits reached 496.66 crore from 996.66 crore in collections. The overall financial recovery remains healthy, though Batwara 1947 adds uncertainty. 🎬
business Ajay Devgn surpassed 1375 crore in net collections post-COVID thanks to the performance of Dhamaal 4. This milestone was achieved in the Indian box office while Dhamaal 4 earned 177.75 crore in 39 days. His previous post-COVID total was 1197.87 crore before this latest release. Despite mixed reviews for the film, its performance contributed significantly to his overall tally. With Drishyam 3 coming in October, he is set to cross the 1500 crore mark.
business Spider-Man: Brand New Day is a massive hit, becoming the first film of 2026 to surpass the $2 billion worldwide mark. The Tom Holland starrer is performing incredibly well in North America, hitting $786.8 million in just 17 days. Internationally, the film has earned $1.2 billion, bringing its global total to $2.02 billion. It has earned a 259.5% gain on its $562.5 million break-even target in only seven days. The movie, released on July 31, is projected to earn between $2.5 billion and $2.7 billion globally. 🕷️
health Three dengue vaccines have received global regulatory approval, including Qdenga, Dengvaxia, and Butantan-DV. Takeda's Qdenga got approval in India on July 2026 from CDSCO, targeting ages 4–60. Clinical data shows Qdenga has 80.2% efficacy against dengue and 90.4% against hospitalization. Vaccination can potentially affect diagnostic tests like RT-PCR shortly after administration. The future market will integrate vaccination, diagnostics, and surveillance efforts. 💉
health A Danish cohort study investigated whether piperacillin-tazobactam resistant blood infections increase mortality risk. Researchers analyzed 34,379 patients with E coli or K pneumoniae BSIs from November 2018 to November 2024. Crude mortality was higher for resistant infections initially, but this difference vanished after adjusting for risk factors. The study concludes that TZP resistance does not equate to a higher mortality risk in this Danish cohort. This finding is relevant given rising resistance concerns in Denmark. 🧐
entertainment The Tamil action thriller DC is doing well at the box office despite strong competition from Suriya’s Viswanath & Sons. The film has reached a net total of 56.76 crore in India after 11 days domestically. This achievement makes DC Wamiqa Gabbi’s third highest-grossing film in India. Currently, the movie is on track to potentially surpass her 2025 Hindi film, Bhool Chuk Maaf. However, upcoming releases in Kerala might impact DC's future collections. 🎬
business A debate is happening among some Tata Sons directors regarding the official response to chairman N Chandrasekaran's decision not to seek reappointment. Sir Dorabji Tata Trust (SDTT) wrote to the board suggesting a selection committee to find a successor. This discussion follows Chandrasekaran's sudden decision, leading to uncertainty about the August 18 AGM. Directors are split on whether to vote on the issue or ask him to reconsider his choice. This situation reflects unease around an unexpected leadership transition at Tata Sons.
The final day to sign up for The Hindu Made of Chennai Run 2026 is August 19. The event is set to happen on August 23 at Besant Nagar beach in Chennai. Registration fees are ₹699 for the 5K and ₹799 for the 10K run. This run is presented by Casagrand and co-powered by AU Small Finance Bank. Interested participants should register soon via the provided link.
business HR and payroll provider Darwinbox is seeing buyout interest from giants like Microsoft and Salesforce. These companies are interested while Darwinbox prepares for a potential IPO over the next few years. The KKR-backed firm is now estimated to be worth around $1.8-2.0 billion. This interest comes as Darwinbox expands globally, offering founders and investors new exit options. The board is currently deciding on the multiple offers the company is receiving. 🚀
tech Anthropic's annualized revenue run rate surpassed $65 billion by the end of July, according to Bloomberg. This figure is up significantly from $47 billion reported in May and just $9 billion last year. Investors anticipate this growth trajectory to continue, aiming for between $100 billion and $120 billion by the end of 2026. Meanwhile, rival OpenAI has doubled its revenue to $40 billion as of the end of 2025. Anthropic is expected to debut publicly soon, targeting a $2 trillion valuation. 🚀
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