π§ Scientists cracked brain medicine delivery code
Caltech scientists developed BrainCAB, a new system to get medicines past the blood-brain barrier. This breakthrough was achieved by modifying a glaucoma eye drop, brinzolamide, to act as a molecular shuttle. The technology leverages the CA-IV enzyme found on brain blood vessels to transport cargo. Testing in rodents showed BrainCAB significantly increased antibody delivery to the brain. Further preclinical work is ongoing before human clinical trials can commence. π¬