π¬ RNA breakthrough offers hope for genetic diseases
Researchers at the University of Toronto developed a next-generation RNA therapeutic approach targeting genetic disorders. Led by Bowen Li, the study focused on transfer RNA (tRNA) to fix 'nonsense mutations' causing diseases. These mutations account for about 11% of inherited disorders and affect thousands of conditions. The engineered tRNA successfully restored protein in cystic fibrosis models when combined with existing drugs. The team is now exploring inhaled treatments for lungs and other organs. π§¬