🧬 New drug targets tough blood cancers via MYC and GSPT1

Researchers at MD Anderson Cancer Center discovered a new feedforward relationship between MYC and GSPT1 in various blood cancers. The experimental drug GT19630 was developed to disrupt this cycle in leukaemia, lymphoma, and multiple myeloma. Preclinical tests on January 2024 showed strong anti-cancer activity, even against TP53-mutated disease. This mechanism also showed promise in overcoming resistance to venetoclax in AML. Further studies are needed to confirm the safety and efficacy of this approach in patients.

🔬 Drug keeps HIV viral suppression high in French study

Dolutegravir-Lamivudine showed high viral suppression rates in a 3-year French real-world study. Researchers monitored 304 participants across 49 centers in France from 2020 to 2024. Nearly 90% of treatment-naive individuals suppressed the virus within 6 months, while 94% of pretreated patients maintained suppression. This indicates strong virological success with a favorable safety profile, showing stable body weight. Future studies need to look at longer-term results in different populations. 🔬

🏎️ Lamborghini brings back patriotic Tricolore on new Temerario

Lamborghini has revived the Tricolore nameplate for a one-off Temerario, showcasing its Ad Personam craft at Monterey Car Week. This special edition is dressed in the Italian flag's colours, marking its return after 15 years from the 2011 Gallardo. The Temerario features a 4.0-litre twin-turbo V8 paired with three electric motors, delivering 920 hp and 0-100 km/h in 2.7 seconds. CEO Stephan Winkelmann stated this car celebrates Lamborghini's values of design, innovation, and Italian craftsmanship. Currently a showcase piece, it demonstrates the expansive possibilities of Lamborghini's customization options. 🇮🇹

🎬 Bethlehem Kudumba Unit crushes weekend box office

The rom-com Bethlehem Kudumba Unit is performing strongly at the box office. It stars Nivin Pauly and Mamitha Baiju and was directed by Girish AD. The film earned 20.85 crore in India over three days, plus 36.7 crore overseas, totaling 61.4 crore worldwide. This performance puts it 17.9% ahead of Sarvam Maya’s opening weekend collection, which earned 17.9 crore. The movie continues to draw strong audience support for its story of first love and second chances. 💖

💡 Kitchen foil could ditch costly terahertz polarizers

Australian researchers found a simple way to create terahertz polarizers using ordinary aluminium kitchen foil. The team at ANU developed this method by using a nanosecond laser to etch microscopic grids onto the foil. This process takes as little as 15 seconds and bypasses expensive cleanrooms and specialized fabrication. These tiny components are vital for controlling terahertz light, which can see through materials without X-rays. The new approach promises cheaper and faster production for these fundamental scientific tools. 🔬

🌍 how democracy evolved over the last 200 years

Elections, voting rights, and political competition have developed globally over the last two centuries. Historically, leaders were often chosen by inheritance or force in the late 18th century. By the second half of the 20th century, elections became the main way to pick leaders worldwide. Although progress is seen, dozens of countries have become less democratic in the last decade. The current trend shows a shift from rule by blood to rule by election. 🗳️

🔥 Hanuman Ansh's massive box office comeback 🚀

Hanuman Ansh, starring Chandan Anand, saw an unbelievable 595% jump in its third weekend compared to week two. Released on August 7, the film initially performed poorly, earning only 89 lakh in the first week. Screen counts drastically increased from 40 to 400 in week three due to positive word-of-mouth. The third weekend brought in 3.2 crore, with day 17 netting a massive 2.18 crore. Overall, the movie has now gathered 4.55 crore net at the Indian box office.

🎮 Dawnwalker finally gets 60 FPS mode after backlash

The Blood of Dawnwalker will receive a Performance Mode targeting 60 FPS across key consoles. This update was revealed by Bandai Namco and Rebel Wolves over the weekend. The feature will be included in the launch patch on Day 1 for PS5, PS5 Pro, and Xbox Series X. The developers acknowledged player feedback regarding console performance and prioritized testing. The game is set to launch on September 3 for PS5, Xbox Series X|S, and PC. 🎮

🎬 Khalifa trails Aadujeevitham by 60% post opening weekend

Prithviraj Sukumaran's film Khalifa has seen a significant drop at the box office after its August 20 release. It was released in theaters, but poor word-of-mouth hurt its performance against competitors. Over its 4-day opening weekend, Khalifa earned a net total of 11.9 crore, with an overseas gross of 16.25 crore. This puts it trailing Aadujeevitham by 60% in the opening weekend comparison. The film might end up being Prithviraj’s third consecutive failure. 📉

🍪 Yeast turns plastic and crop waste into protein cookies

Scientists engineered yeast to convert PET plastic and crop residues into edible proteins and vitamins. This breakthrough was achieved by researchers at Southern Illinois University Carbondale. The process involves using genetically programmed yeasts on materials like discarded corn stalks. This technology offers a novel way to recycle plastic while aiding food production in tough spots. The team plans to present their findings at the ACS Fall 2026 meeting in Chicago. 🍪

🦠 Microplastics linked to rheumatic diseases 🔬

Evidence suggests microplastics, fragments between 1 nm and 5 mm, may harm people with rheumatic diseases. Stanford's Tamiko Katsumoto noted that gut barrier disturbance from ingestion could worsen inflammatory conditions. An estimate indicates 10-40 million tons enter the environment yearly, set to double by 2040. Studies show high microplastic exposure correlates with higher stroke and diabetes risks. Researchers are investigating if these particles act as environmental stressors amplifying inflammation.