🔬 New ASCO 2026 guidelines change NSCLC treatment

The ASCO Living Guideline Version 2026.3.3 now emphasizes molecular profiling over just histology for Stage IV NSCLC. Clinicians must now use broad multigene profiling before starting systemic therapy, even if PD-L1 is high. For EGFR mutations, ASCO recommends intensifying frontline therapy with combination options like osimertinib plus platinum-pemetrexed. Furthermore, EGFR exon 20 insertions finally have a true targeted frontline choice with sunvozertinib or platinum-doublet chemotherapy plus amivantamab. These updates shift precision oncology into a more complex, risk-adapted phase. 🔬

⚽ Newcastle edge Spurs despite Tonali's poor showing

Newcastle managed to secure a victory against Tottenham in a recent match. Sandro Tonali struggled significantly while playing against his former club, Newcastle. The game took place on a specific date, though exact figures are not detailed here. This performance highlights the competitive nature of the Premier League fixtures. Fans will be watching closely to see how this impacts the league standings moving forward. ⚽

💔 Milvexian fails to cut heart attack risks in ACS patients

The LIBREXIA ACS trial found that Milvexian did not reduce major adverse cardiovascular events compared to placebo after acute coronary syndrome. This study took place at ESC Congress 2026 and was published in the New England Journal of Medicine. The trial involved 14,194 participants across 44 countries with a median follow-up of 10 months. The research team discontinued the trial in November 2025 due to futility at an interim analysis. Importantly, there was no increase in intracranial or fatal bleeding observed between the two groups.

🧐 BJP slams TVK government over religious politics in Assembly

BJP State president Nainar Nagenthran accused the TVK-led government of letting religious politics into the Tamil Nadu Assembly. He criticized Speaker J.C.D. Prabhakar for showing religious bias while in his chair. Nagenthran pointed out that Finance Minister N. Marie Wilson presented the budget with a rosary and cited Bible verses. This action, he claimed, compromises the House's neutrality and dignity. He urged TVK ministers to stop bringing personal religious matters into legislative proceedings. 🧐

✨ Condemned mansion turns into $4.5M dream home

An artist bought a condemned 1888 Victorian mansion in San Diego's Bankers Hill neighborhood back in 1997. She spent eight years meticulously restoring the property, which now boasts over 30 chandeliers and a secret bar. The house features columns salvaged from the Titanic movie set and is now listed for a staggering $4.5 million. This restoration blends historic landmark status with high-end, cinematic luxury. It stands out as a major outlier in the local historic housing market. 🤩

🏏 Gubbins and Orr boost Hampshire's innings momentum

Gubbins and Orr managed to wrestle back the momentum for Hampshire in the ongoing match. They achieved this feat while playing in the current venue. Specific details regarding scores or dates were not provided in the source material. This resurgence is key for the team to challenge the current standings. The focus now shifts to how the rest of the team performs moving forward. 🏏

🏔️ Nepal, Tibet disasters spotlight Uttarakhand's risky glacial lakes 🏔️

Recent natural tragedies in Tibet and Nepal have ramped up worries about Uttarakhand's glacial lakes. The National Disaster Management Authority has flagged 13 lakes as potentially dangerous, with five facing GLOF threats. The central government has approved Rs 30 crore for early warning systems, with Rs 8.10 crore already released. However, setup is delayed due to terrain and technical hurdles in districts like Chamoli and Uttarkashi. Timely monitoring is crucial to prevent major life and property loss from potential floods.

🌌 Universe mass measurement is way trickier than thought

Scientists have traditionally estimated the Universe's mass using the Initial Mass Function (IMF) based on visible stars in galaxies. However, a team at the University of Missouri found that the IMF, currently biased towards larger stars, contains flawed assumptions. They used Gaia satellite data on Milky Way clusters to show that different clusters have varying stellar mass ratios. This means a single, universal IMF model is likely incorrect for accurately calculating galactic mass and evolution. Astronomers can now factor in specific star-forming environments for better cosmic measurements. 🔭

🕉️ Bhagwat: No place for excluding Muslims in Hindu thought

RSS chief Mohan Bhagwat emphasized Hindu inclusiveness during his address at Madison Square Garden. He stated that a Hindu wanting India without Muslims would not remain Hindu, arguing for societal change over political power. This was said on Saturday at the "Universal Oneness Celebration" in New York. Bhagwat stressed that diversity must be accepted, respected, and protected for humanity's sake. He urged leaders to promote unity through local service and dialogue moving forward. 🕉️

💔 Heart attack patients face higher bleeding risk with new drug combo

Potent antiplatelet therapy increased bleeding risk without showing any benefit for cardiovascular events in patients with atrial fibrillation after a heart attack. This key finding came from the EPIDAURUS trial, conducted at 37 sites in Germany and Austria. The study compared a potent inhibitor combo versus a control group, which was prematurely stopped after 602 patients enrolled. The experimental group showed more than threefold higher rates of significant bleeding compared to the control group. Therefore, the results do not back the routine use of these potent P2Y12 inhibitors in this patient group. 💔

🎮 Xbox's Project Helix is a multi-device lineup, not just one console

Xbox's Project Helix will be a 'great family of devices' rather than a single console, according to CEO Asha Sharma. This announcement was made by Sharma at gamescom 2026, diverging from earlier March framing. Alpha units are expected in 2027, with a potential consumer launch around the holidays in 2027. This strategy aligns with Microsoft's 2025 partnership with AMD for a 'portfolio of devices.' The company will share more details soon as the gaming industry shifts towards digital formats. 🎮