🔬 Maintenance therapy vs surveillance in mCRC: what's the tea?

Maintenance therapy showed longer overall survival than active surveillance for metastatic colorectal cancer patients who controlled their disease after bevacizumab chemo. The study, done at a single center, looked at 94 patients between January 2015 and December 2025. The maintenance group had a median OS of 24.8 months versus 18.0 months in the surveillance group. However, this survival benefit disappeared when adjusting for initial prognostic factors. Future research needs to confirm these findings given the study's retrospective nature. 🧐

🩺 Fast DNA test could save newborn hearing

Rapid genetic screening can identify newborns at high risk for permanent hearing loss from certain antibiotics. This was studied by Erasmus University Medical Center in Rotterdam, Netherlands, using the MT-RNR1 gene variant. In a 2022 trial of 751 newborns, results were available in under 26 minutes. This shows pharmacogenetics can work in time-critical ICU settings. Now, official recommendations are being updated globally for better newborn care. 👶

🦴 Denosumab beats Alendronate for bone density in RA patients

Denosumab showed better improvement in lumbar spine bone mineral density compared to alendronate for postmenopausal women with RA on glucocorticoids. The study, conducted in China, involved 295 patients between January 2018 and December 2023. Denosumab patients saw a mean difference of 0.444% in BMD after one year. While denosumab had a numerically higher fracture rate at 8.1% versus 1.6%, this difference wasn't statistically significant. Further large-scale studies are needed to confirm the comparative effectiveness of these treatments.

🩺 Weight loss meds help breast cancer survivors?

A phase 2 trial suggested that adding a non-GLP-1 weight-loss drug could help some breast cancer survivors reach their target weight. This study was conducted by researchers at Johns Hopkins Sidney Kimmel Comprehensive Cancer Center in Baltimore. The trial enrolled 55 women, and 42% of those who needed extra help successfully reached a 5% weight loss threshold by six months. This intervention was used for women who couldn't lose weight enough through lifestyle changes alone. Larger studies are needed to confirm this threshold-based approach for prescribing these medications. 🩺

🔬 Ubiquitin code unlocks new drug frontiers

Protein-degrading drugs, leveraging the cell’s ubiquitin system, are revolutionizing medicine. FDA approved Veppanu for breast cancer and Zenbexus for multiple myeloma in May and August this year. These drugs use ubiquitin, a small protein, to selectively destroy problematic proteins within cells. Understanding the complex 'ubiquitin code' is helping design targeted therapies for cancer and more. Researchers anticipate a major shift in the pharmaceutical industry due to this research. 🧬

🩺 Antiseizure med linked to higher clot risk with DOACs

New data suggests levetiracetam might increase the risk of thromboembolic events when used with DOACs. This was found in a retrospective study involving over 9000 adults with epilepsy across 165 healthcare organizations. The study compared levetiracetam against lamotrigine or lacosamide, finding a nearly twofold higher risk for the former. This prompts caution since levetiracetam was previously thought to have low drug interaction potential. Clinicians should actively review ASM choice to manage anticoagulation safety going forward. 🩺

🔥 Nivin Pauly's film hits big box office numbers

Nivin Pauly's film, Bethlehem Kudumba Unit, is performing very strongly at the ticket windows. The Malayalam film stars Mamitha Baiju and is currently doing well across India. In just 72 hours, it recovered nearly 70% of its 30 crore budget. On Sunday, August 23, day 3, it earned between 8.5 to 9 crore. The film aims for a total net collection of 60 crore to be declared a hit. 🚀

🍲 Chennai's food scene: tiffins to apps

Chennai's food culture has drastically shifted from traditional home-cooked meals to modern food apps and cafes. Writer Sivasankari remembers Madras of the 1960s and 1970s, where eating out was rare and home food was key. The city saw major changes around the year 2000 with the rise of malls and eateries. Now, spots like Dashamakan and Anna Nagar have become vibrant food hubs. Despite changes, local favourites like Jannal Kadai still manage to thrive. 🍜

⛏️ Odisha fears mineral control loss from new central act

Former CM Naveen Patnaik urged CM Mohan Charan Majhi to convene a special session regarding the MMDR Amendment Bill, 2026. This bill was passed by Parliament on August 13, with Odisha holding 43.49% of mineral value. The act allows the Union control over mineral-bearing lands and bans state levies on mineral rights. Stakeholders fear this erodes Odisha's authority and fiscal interests, affecting tribal communities. Patnaik warns this shift leaves Odisha only with pollution burdens. 😥

🌳 New baobab species spotted in Madagascar 🌳

Genetic analysis has identified a distinct baobab species, Adansonia bozy, within Madagascar. Researchers from the University of Wisconsin-Madison found this species was previously grouped with Adansonia za on the island. This discovery, published in Taxon, suggests the need to rethink conservation strategies for these endangered trees. Separating the species could redirect crucial conservation resources toward A. bozy's protection. Scientists plan to continue studying Madagascar's baobabs to understand the island's full biodiversity.

🧐 Former Envoy Navdeep Suri Issued Notice by Punjab SIR

Punjab SIR has issued a notice to former envoy Navdeep Suri demanding the production of certain documents. This action involves Suri, who is a former diplomatic representative, and the proceedings are taking place under the jurisdiction of Punjab SIR. The notice was issued recently, calling for the necessary documentation by a specified deadline. This legal move stems from ongoing inquiries related to his past official duties and responsibilities. Further legal steps will depend on his compliance with this official demand. 🧐