π¬ Fungus' Titan Cell secret revealed by CCMB
CCMB scientists discovered a biological circuit enabling the dangerous fungus Cryptococcus neoformans to form protective 'Titan cells'. This research, led by Dr Sriram Varahan in Hyderabad, links glucose metabolism to calcium signalling and calcineurin activation. Cryptococcal meningitis affects over 1.5 lakh people globally each year, making this discovery significant. The findings present a new target for antifungal therapies, moving beyond just killing the pathogen. This mechanism exposes a vulnerability in the fungus's survival strategy. π¬