health π¬ Drug combo cuts uric acid stone volume
Phentermine/topiramate helped reduce uric acid stone volume in patients with obesity and diabetes during an 18-month trial. Nineteen participants were randomized to the drug or controls for the study. In the per-protocol analysis, stone volume saw a statistically significant drop with the intervention. This group also achieved more weight loss and better HbA1c reduction than the controls. These results suggest more research is needed for broader uric acid stone management. π¬