science 🧠 Brain structure changes spotted 7 years before Alzheimer's plaques
New MRI data suggests brain cortical thickness changes can happen up to seven years before amyloid plaques appear in Alzheimer’s disease patients. Researchers combined longitudinal MRI data with amyloid-beta (Aβ) PET imaging to spot these subtle structural shifts. The analysis showed thicker cortical regions in those who later developed elevated Aβ plaques compared to Aβ-negative individuals. This evidence points towards earlier structural alterations potentially signaling future AD development before high amyloid burden is visible. Further studies are required to confirm how these structural changes connect with amyloid accumulation. 🧠