π§ Brain protein links fat cravings to obesity
A hidden brain protein named OPA1 appears to influence resistance to high-fat foods, which is a major global health challenge. Professor Shigenobu Matsumura's team at Osaka Metropolitan University studied this protein in mice. Findings showed that removing OPA1 caused both male and female mice to become obese when fed soybean oil. Furthermore, the anti-obesity drug setmelanotide worked in males but barely affected OPA1-deficient females. This suggests future weight-loss treatments must be personalized based on biological sex. π§