health π§ Brain changes linked to depression's severity over time
A 10-year study linked grey matter volume changes in major depressive disorder to cumulative illness severity. The research was conducted within the MΓΌnster Neuroimaging Cohort, tracking inpatients and controls. The analysis involved 206 individuals over up to 10 years, with repeated MRI scans. Higher cumulative illness severity was associated with a steeper decline in hippocampus and prefrontal cortex volume. This suggests a need for personalized, trajectory-based models for depression treatment moving forward. π§